Kumail Nanjiani Performs at the Julia Louis-Dreyfus Mark Twain Prize.

Ilana Glazer & Abbi Jacobson perform the "Elaine Dance."

Keegan-Michael Key Performs at the Julia Louis-Dreyfus Mark Twain Prize.

Celebrating the work of "Late Night" and "The Late Show" legend David Letterman, the latest recipient of The Kennedy Center Mark Twain Prize for American Humor. From the stage of The John F. Kennedy Center, a star-studded lineup salutes the achievements of the late-night broadcaster.

David Letterman Gives His Acceptance Speech For The 2017 Mark Twain Prize.

Steve Martin & Martin Short Perform At The David Letterman Mark Twain Prize.

Jimmy Kimmel Performs at the David Letterman Mark Twain Prize.

Amy Schumer Performs at the David Letterman Mark Twain Prize.

John Mulaney Performs At The David Letterman Mark Twain Prize.

Bill Murray Performs at the David Letterman Mark Twain Prize.

Bill Murray meets with President Obama while in Washington, D.C. to accept The Kennedy Center Mark Twain Prize for American Humor.

Jimmy Kimmel reminds you not to miss Bill Murray: The Mark Twain Prize.

Watch Bill Murray accept The Kennedy Center Mark Twain Prize.

"Ghostbusters" director Ivan Reitman recounts how he first met Bill Murray.

Why is Bill Murray so elusive & hard to reach? Hear Jimmy Kimmel's insightful answer at the Mark Twain Prize.

Jimmy Kimmel, Sigourney Weaver, Bill Hader & more talk about how Bill Murray would react/celebrate/possibly die if the Chicago Cubs win the World Series.

Watch comedy legend Bill Murray accept the 2016 Kennedy Center Mark Twain Prize for American Humor.

Watch Bill Hader and many others salute comedy legend Bill Murray at the 2016 Kennedy Center Mark Twain Prize for American Humor honoree.

From the stage of the John F. Kennedy Center, watch Aziz Ansari celebrate the achievements of comedy great Bill Murray at the 2016 Mark Twain Prize for American Humor.

David Letterman and more celebrate the achievements of the Kennedy Center Mark Twain Prize for American Humor recipient Bill Murray.