The world urgently needs an effective COVID-19 vaccine. Behind much of the research is Bill Gates, who is dedicating billions of dollars to helping ensure that when a vaccine arrives, it will be affordable and accessible to those most in need. He speaks with Walter Isaacson about his belief that much of the testing being done in America is a complete waste.

Andrei Sannikov was once Belarusian President Alexander Lukashenko’s deputy foreign minister, but they are emphatically no longer allies. Sannikov ran against the president in 2010 and came in second, only to be jailed shortly afterwards and subjected to horrifying treatment. He joins the program from Warsaw, Poland, where he is living in exile.

President Trump, still fighting to hide his financial history, now demands that the Manhattan District Attorney reveal why he issued a subpoena for eight years of tax returns and other documents. Trump’s lawyers argue the president is being “harassed.” Christiane speaks with legal analyst Jeffrey Toobin to discuss this as well as Toobin’s new book on the Mueller Investigation.

Beijing’s crackdown on democracy in Hong Kong has re-escalated with the latest high-profile arrest under the new national security law. Claudia Mo spent 30 years as a journalist in the region and now serves as an independent pro-democracy member of the Legislative Council. She joins the show to discuss.

David Kaye served for six years as the United Nations’ Special Rapporteur on the Promotion and Protection of the Right to Freedom of Opinion and Expression, and he joins Hari Sreenivasan to discuss how the pandemic has prompted the newest tactic in the authoritarian leadership playbook.

To discuss the best way forward for the country’s ailing healthcare system, Christiane speaks with progressive Saikat Chakrabarti, who served as chief of staff to Rep. Alexandria Ocasio-Cortez, and Jennifer Granholm, the former governor of Michigan.

Lebanon's economy and food security are at a breaking point, and calls for change have been years in the making. The same factions have ruled Lebanon for decades, and many accuse them of benefiting from corruption while ordinary people starve. Lebanon's Former Deputy Prime Minister Ghassan Hasbani joins the program to discuss.

Mona Fawaz is Professor of Urban Studies at the American University of Beirut and an active critic of the government in Lebanon. She and her family were in Beirut at the time of Tuesday's explosion. She joins Christiane to discuss her experience and assess the government's response to the situation.

Remember the name Theranos? It was touted as a revolutionary blood-testing start-up--until 2018, when it came crashing down and its founder, Elizabeth Holmes, was charged with fraud. Tyler Shultz worked at the company before becoming a whistleblower about the technology, which didn't actually work. He joins Hari to discuss lessons learned as it relates to the hunt for a COVID-19 vaccine.

A suit filed in Washington, D.C. raises stunning new allegations against Saudi Crown Prince Mohammad Bin Salman. Dr. Saad Al-Jabri, a former top Saudi intelligence official, claims Bin Salman sent an assassination squad to kill him just two weeks after the brutal murder of journalist Jamal Khashoggi. His son joins Christiane from Toronto for this exclusive interview.

New York Times Investigative Correspondent Mark Mazzetti is running down the latest allegations against the Saudi leadership, as well as new reports that Saudi Arabia may be moving toward developing a nuclear weapon. He joins Christiane from Washington to discuss.

In his new book, political strategist Stuart Stevens turns on his old party. Titled "It Was All a Lie: How the Republican Party Became Donald Trump," the book argues President Trump is the natural outcome of five decades of Republican hypocrisy and self-delusion.

What's at stake for voters when a president and his party drum up fears about an election's integrity? LaTosha Brown is a community organizer, political strategist and co-founder of the Black Voters Matter Fund, and Ari Berman is an author and senior reporter at Mother Jones. They tell Hari Sreenivasan what voters must watch out for this fall.

Christiane speaks with one of the few remaining survivors of Hiroshima: 88-year-old Setsuko Thurlow, who became an activist after surviving the bombing and received the Nobel Peace Prize on behalf of the international campaign to abolish nuclear weapons in 2017. She recounts the agonizing memories and explains why there is reason for hope.

This year, a historic British Vogue September issue highlights activists in the fight for racial justice. The cover was the work of Misan Harriman, the first Black photographer to shoot a September cover, backed by an all-Black team. The cover features soccer star and anti-poverty campaigner Marcus Rashford and model and mental-health activist Adwoa Aboah. Harriman tells Christiane about his work.

Oprah Winfrey says Isabel Wilkerson's book "Caste: The Origins of Our Discontents" is a game-changer and the most important volume she's ever chosen for her book club. Wilkerson was the first Black woman to win the Pulitzer Prize for journalism. Her latest book calls out America's obsession with the term "race."

Global pandemic notwithstanding, President Trump has launched an on-again-off-again verbal war against America's leading infectious disease expert: his task force adviser, Dr. Anthony Fauci. The president recently tweeted that Fauci was "wrong" that the surge in cases is due to the country's failure to shut down properly. Fauci joins Walter Isaacson to discuss the challenges facing the U.S.

Poll after poll shows President Trump's support in steady decline, with many voters citing the pandemic response and racial equality as key election issues. Will the campaign change its strategy? Joining Christiane from Virginia to answer that question is Steve Cortes, a Trump 2020 senior adviser.

Lebanon - one of the worst hit Middle East countries from coronavirus, and teetering on the brink of economic collapse, has now been hit by a massive explosion in the capital of Beirut. Local authorities are warning that many are injured and buildings across the city have been damaged. CNN reporter Ben Wedeman was standing by on the ground for this special report.

In Mississippi, which is on track to be the top state for coronavirus infection, the school district in the city of Corinth re-opened its doors last week. Dr. Edward Lee Childress is Superintendent in Corinth. After reopening schools in his district, positive cases of COVID-19 emerged immediately. He speaks to Christiane about how his district is managing.