As the world grapples with the humanitarian fallout in Afghanistan, former four-star U.S. General Stanley McChrystal is watching it unfold knowing all too well what's on the line. McChrystal was the Commander of American and coalition forces in Afghanistan. He drew on this experience in his new book, "Risk: A User's Guide." He joins Walter Isaacson to discuss the major global threats.

Afghanistan, home to 38 million people, is running out of food and money. The White House is making it clear it wants to provide assistance directly to the Afghan people. Joining Christiane is Fawzia Koofi, a former Afghan politician who was part of the team negotiating with the Taliban, and -- from Kabul -- Mary-Ellen McGroarty, the World Food Programme's Director for Afghanistan.

Columbia law professor Kimberlé Crenshaw is world-renowned for her work on racism and sexism in America. Preeminent in her field, she coined the term "intersectionality" back in 1989. In a recent essay for The New York Times, "How R. Kelly Got Away With It," Crenshaw argues that the R&B star was able to dodge justice for so long because of a "societal disregard for Black women.

We turn to two Hollywood brothers who made their names in some of America's best-loved family classics. Ron and Clint Howard were the child stars of hit shows like "Happy Days" and "Gentle Ben." You might not know Clint as well as Ron, but both had successful performing careers. Despite that, it's their decades of brotherhood that they've chosen to celebrate in their new joint memoir "The Boys."

Feldstein stars in the latest dramatized version of a story that grabbed global headlines and led to the impeachment of then-President Bill Clinton. "Impeachment: American Crime Story" on FX has the full backing of Monica Lewinsky herself, the central figure in this real-life drama. Onscreen Lewinsky is played by actress Beanie Feldstein, best known for her roles in "Ladybird" and "Booksmart."

Doctors Ugur Sahin and Özlem Türeci changed the course of history when their company BioNTech, alongside Pfizer, developed the first clinically approved COVID-19 vaccine. The shot was found to be 90% effective in preventing disease. The work of doctors Sahin and Türeci has saved countless lives. The doctors now turn their focus to booster shots and to deadly diseases like malaria and tuberculosis.

In its 138-year history, the Metropolitan Opera has never hosted a performance by a Black composer -- until now. Terence Blanchard's new work is based on a 2014 memoir by New York Times columnist Charles Blow. The composer speaks with Walter Isaacson about his artistic process.

In just three weeks, world leaders meet in Glasgow for the COP26 climate conference, where they'll reckon with a dispiriting report from the United Nations showing that the world is warming faster than scientists previously thought. Danish Prime Minister Mette Frederiksen is on a state visit in New Delhi now, to convey the urgency of the climate crisis.

"Polexit," anyone? The term is tentatively being bandied about since tensions in Poland reached boiling point over EU membership. Meanwhile in the U.K., home of "Brexit," the economic chickens are coming home to roost with food industry supply chains in utter chaos. Michel Barnier, the EU's unflappable Brexit negotiator, has laid out his experience in a new book called "My Secret Brexit Diary."

A new ProPublica article by journalist Sarah Smith caught our eye with this warning: "We are losing our humanity." Visualize school meetings turning toxic over masks, and medical centers disrupted by violence. Is the new reality fundamentally altering our behavior and the way we interact? If so, what will the lasting impact be? To help unpack all this, we're joined by sociologist Eric Klinenberg.

For the second straight month, the U.S. economy has added far fewer jobs than expected -- only 194,000 in September. Yet the unemployment rate declined as well. What do these numbers tell us about the outlook for workers, businesses and families?

Dave Eggers has just released a gripping sequel to his bestseller "The Circle." "The Every" imagines an Amazon-Facebook type company that becomes the richest and most dangerous monopoly ever known. He speaks with Walter Isaacson about the new work.

Minnesota Attorney General Keith Ellison is suing ExxonMobil, the American Petroleum Institute and Koch Industries, claiming they have deceived the public over the effects of climate change.

In 2018, the world was mesmerized by the life-and-death story of 12 schoolboys and their soccer coach trapped in a flooded cave in Thailand. A new documentary dives into this story with never-before-seen footage. "The Rescue," by Academy Award-winning directors Elizabeth Chai Vasarhelyi and Jimmy Chin, reveals the peril of the daring mission. They speak with Hari about the miraculous rescue.

As the COVID-19 pandemic rages on, there is welcome news in the fight against another deadly infectious disease: malaria. The World Health Organization has approved the first-ever malaria vaccine for use among children. Meanwhile, in the U.S., Pfizer is formally asking the FDA for emergency-use authorization of its COVID-19 vaccine for children aged 5-11. Here to discuss is Dr. Sanjay Gupta.

The Biden administration is warning that the U.S. is prepared to sanction those responsible for ferrying weaponry during Ethiopia’s war effort in Tigray. Here to discuss this and other pressing matters is the ranking Republican on the House Foreign Affairs Committee, Congressman Michael McCaul.

Imagine traveling to outer space just as the pandemic started--only to return months later to a whole new earthly reality. This was the case for Chris Cassidy. The NASA astronaut took his final space mission last April to the International Space Station in a quest to find the origins of the universe. It’s all captured in a new Disney docuseries, "Among the Stars." Cassidy joins the show.

From the women's marches following President Trump’s 2016 victory to his defeat four years later, women have turned the tide in Washington – that’s according to Washington Post columnist Jennifer Rubin. Her new book explores how female voters, activists and politicians fought for democracy. She speaks with Michel Martin about her own political reckoning.

Ambassador J. Peter Pham, who served as the first-ever U.S. Special Envoy to the Sahel Region of Northern Africa, now sits on the Atlantic Council. He joins the show from Washington to discuss how Ethiopia’s Nobel Peace Prize-winning prime minister has become an international pariah.

In New York City, homelessness has long been an issue. The latest numbers show more than 45,000 people living in shelters. This was Dasani Coates’s reality in 2012, when she was just 11 years old. Now she is the subject of a new book, "Invisible Child: Poverty, Survival and Hope in an American City," by Pulitzer Prize-winning journalist Andrea Elliott. It draws on almost a decade of reporting.