25 million coronavirus cases have now been reported in the U.S., with vaccines a rare light at the end of the tunnel – despite ongoing problems in their rollout. Two ER doctors on the front line join Hari Sreenivasan to explain how more lives can be saved through earlier diagnosis.

The Biden administration is already facing a major diplomatic test, as this weekend saw demonstrators in Russia coming out in huge numbers to protest the detention of opposition leader Alexey Navalny. What significance do these protests hold, and how should the Biden administration respond? International relations experts Evelyn Farkas and Nina Khrushcheva join Christiane to discuss.

A new documentary, "The Human Factor," looks at Israel-Palestinian peace efforts through the eyes of key American negotiators. The film examines the personal stories hidden within this complicated, historic conflict. Director Dror Moreh joins Christiane alongside two key players featured in the film: a veteran Middle East negotiator Aaron David Miller and former senior policy adviser Gamal Helal.

This week, the EU invited President Biden to a summit focused on shared multilateral goals, COVID, and climate. Prime Minister Micheál Martin, referring to Biden's Irish ancestry, has said, "He is one of us, part of our global family." Martin joins Christiane from Dublin to react to Biden's inauguration and discuss the state of the pandemic in Ireland.

President Biden has unveiled a new national strategy to replace the ad-hoc patchwork of policies from 50 states under the previous administration. The plan is to pick up the pace of distribution to meet the goal of 100 million vaccinations in Biden's first 100 days in office. Andy Slavitt is a senior advisor to the new response team. He joins Hari Sreenivasan to explain the team's upcoming goals.

The pandemic is President Biden’s immediate concern. But his presidency also marks a crucial pivot for America’s overseas alliances. Joining Christiane to assess the future of U.S. foreign policy are former UK diplomat Sir Peter Westmacott and former State Department, Defense Department, and National Security Council official Kori Schake.

Vice President Kamala Harris cracked the penultimate glass ceiling today, marking a historic moment in American politics. There is perhaps no more famous campaigner for women’s rights than Gloria Steinem, who speaks with Michel Martin alongside Farai Chideya, host of the podcast "OurBodyPolitic."

President Biden comes to power pledging to put his whole soul into uniting America. History was also made, as Vice President Kamala Harris became the first African American, first South Asian, and first woman to ever hold that position. To discuss what this day means and where America goes from here, Christiane speaks with two eminent writers and thinkers on the American experiment.

On the night before his inauguration, President Biden led a memorial for the 400,000 Americans who have died from coronavirus. "To heal, we must remember," he said. As we know, Biden's own life has been shaped by tragedy and personal loss. David Kessler, an expert on death and grieving, is the author of "Finding Meaning: The Sixth Stage of Grief." He spoke with Michel Martin.

President Biden is unveiling a national strategy to tackle COVID-19, inviting Congressional leaders to the White House as early as Friday to discuss his plan. Devi Sridhar is the chair of Global Public Health at the University of Edinburgh. She spoke to Christiane about how Biden can best implement a federal pandemic plan.

The United States' allies around the world are wary of the hostile and fractured political climate in the U.S. The Democrats, now in control of the White House and both chambers of Congress, have a long list of urgent priorities. What will happen to them when the Trump impeachment moves to the Senate for trial? Senior Democratic Congressman Adam Schiff joins Christiane to discuss.

Four years of President Trump had led to tense relationships with key allies, including members of NATO -- one of the most important American-led security organizations. Christiane spoke with NATO Secretary-General Jens Stoltenberg about his hopes of rebuilding the transatlantic partnership under a Biden administration.

Since the election, Fox News has been losing viewers to more right wing stations like Newsmax and OANN. Shepard Smith strove to be a credible source of hard news at the network for more than 20 years. In 2019, he left and now anchors his own show on CNBC. He joins the show to discuss what role he thinks Fox News has played in muddying the information ecosystem.

Cedric Richmond is an incoming senior presidential adviser and director of the White House Office of Public Engagement. Richmond has spent the last decade representing Louisiana in Congress and led the Congressional Black Caucus from 2017 to 2019. He speaks with Walter Isaacson about why he believes it’s crucial the new administration works with colleagues across the aisle.

As he finishes his presidency, President Trump has broken yet another norm: pausing executions during a presidential transition. A frenzy of executions has swept through federal death row, more than any presidency in 100 years. To discuss all this, Christiane speaks with human rights lawyer and civil rights activist Bryan Stevenson.

Jeh Johnson, who served as secretary of homeland security under President Obama, cites specific security failures that permitted pro-Trump extremists to gain access to Capitol Hill with so little resistance on January 6. In 2017, Johnson was tasked with overseeing security for Trump’s inauguration. He speaks with Walter Isaacson about the state of national security pending the Biden inauguration.

President Trump is expected to issue a flurry of pardons before he leaves office, when he himself will face many legal and financial issues. With his personal brand tarnished by recent events, what do Trump’s future business ventures look like? Christiane discusses this with the president's niece Mary Trump and Andrea Bernstein, whose hit podcast "Trump, Inc." airs its final episode this week.

President-elect Biden has announced a $1.9 trillion spending package to speed vaccine distribution and provide Americans with immediate financial relief. The plan promises bigger stimulus checks, aid to the unemployed and those facing eviction, and help for small businesses and state and local governments. Christiane discusses the crisis and Biden’s proposed remedies with economist Paul Krugman.

The FBI plays a vital role in protecting the American homeland. Why did the agency abuse its authority to spy on one of the country's greatest civil rights leaders? That question is at the heart of a new documentary titled "MLK/FBI," which examines the Bureau’s ugly obsession with Dr. Martin Luther King Jr. Director Sam Pollard joins the show on King’s birthday to discuss his film.

Getting vaccines to the developing world has been a top priority with Melinda Gates. She is especially aware of the heavy toll the pandemic is taking on women, whose jobs are twice as vulnerable in this crisis to those of men. She takes up these issues in her book "The Moment of Lift: How Empowering Women Changes the World." She joins Walter Isaacson to discuss.