Abbi Jacobson, one of Comedy Central’s biggest stars, joins the program to discuss her hit comedy “Broad City” as well as a new memoir reflecting on love, loss and work.

As we come to grips with the dangers of digital media, Walter Isaacson speaks with Jennifer Pahlka, a tech innovator and founder of Code for America, who argues technology is still a force for good.

As California residents face an unprecedented disaster, in an exclusive interview, Christiane Amanpour speaks to Gov. Jerry Brown about the worst fires in California history.

On her first day in the job, the new head of Planned Parenthood Dr. Leana Wen joins the program to discuss what the organization means to her and its role in a country where healthcare is at the center of political debate.

Timothy Snyder, leading historian and bestselling author, joins the program to discuss the battle of ideas that took place over the weekend in Paris as French President Emanuel Macron hosted world leaders, including President Trump, to mark 100 years since the end of WWI.

In the US, 20 states have filed a lawsuit to repeal pre-existing condition protection from the Affordable Care Act. New York Times bestselling author and journalist Kurt Eichenwald joins the program to discuss what it’s like to navigate the country’s healthcare system with epilepsy, and the struggles he has faced with discrimination, medical incompetence, and sexual abuse.

In the wake of high-profile mass shootings in the US, some doctors are calling for a public health approach to tackle gun violence. Dr. Judy Melinek joins the program to discuss the role of doctors in the gun debate, tensions between some doctors and the NRA, and the #ThisISMyLane and #ThisISOurLane movements.

Wall Street giant Jamie Dimon joins the program from Paris – where he is launching a $30 million investment into Seine-Saint-Denis, one of France’s poorest districts – to discuss the economy, populism, and his spat with President Trump.

In Tuesday’s election, Democratic candidate Tom Malinowski beat his Republican rival in a seat the GOP had held since 1981. A former Assistant Secretary of State for Human Rights under President Obama, Malinowski joins the program to discuss the midterms and President Trump’s foreign policy.

Kurt Andersen is a Peabody Award-winning host of the podcast Studio 360, a best-selling novelist, and acclaimed cultural critic. He joins Walter in studio to examine the growing divide in our nation and how we can reclaim our collective understanding and appreciation for facts and truth in an era of blurred lines.

CNN’s Poppy Harlow sat down recently with Canadian Prime Minister Justin Trudeau to discuss gender parity, trade deals, and Saudi Arabia, and we bring you highlights from that exclusive conversation.

President Obama described Brittany Packnett as a voice to “make a difference for years to come,” and she has campaigned for police reform, was part of the Black Lives Matter movement, and established Teach For America’s first civil rights agenda. Alicia Menendez spoke with her in New York.

The firing of Attorney General Jeff Sessions raises serious constitutional questions, and could risk undermining the Mueller investigation. With Democrats in the House readying to launch investigations, Christiane speaks with Harvard Law Professor Laurence Tribe about what could amount to a constitutional crisis.

President Trump relied heavily during the midterms campaign on stoking up fear of a caravan “invasion,” and deployed troops to the border. In the wake of the election results, Christiane speaks exclusively with the Mexican Foreign Minister to discuss the caravan, and the renegotiation of NAFTA.

New York Times Op-Ed editor and writer Bari Weiss reflects on the midterms results, as well as the recent anti-Semitic massacre in Pittsburgh, where she grew up.

Republican Congressman-elect Dan Crenshaw recently hit the headlines for being the subject of a much-criticised joke on Saturday Night Live about his military injuries, and recently won a congressional seat in his Texas district. He joins the show to discuss where the Republican Party goes from here.

Renowned historian Doris Kearns Goodwin and Amanpour and Company's own Walter Isaacson analyze the broader impact of this year’s midterms, stepping back to place it in a wider historical context.

Political expert John Avlon breaks down the results of the 2018 midterms, looking at what was an especially historic night for women.

Democratic Congresswoman Jackie Speier joins the program to react to the midterm results and what to expect from Democratic control of Congress, as well as discussing her new book on surviving the Jonestown massacre.

Tribalism reigns in Trump’s America, with many voters seeming increasingly isolated from one another, taking refuge in separate political tribes. Award-winning journalist George Packer joins the program to discuss his latest article unpacking the groundbreaking study "Hidden Tribes,” from the group More in Common.