Former Senator Alan Simpson knew George Bush, first as a Congressman; then as President, but also as a father and friend. He spoke to Christiane from Cody, Wyoming.

After more than a year of planning, US Secretary of Education Betsy DeVos has finally unveiled her proposals to overhaul rules governing sexual assault on campus. Anurima Bhargava helped write the Obama-era guidance on the issue, while Samantha Harris from the Foundation for Individual Rights in Education backs the new proposals. They debated the issue with Christiane Amanpour.

The UN warned of a 3.2 degree Celsius temperature rise by the end of this century – woefully short of the two degree goal stated at the Paris Climate Accord. So will we survive the 21st century? 15 years ago, Britain’s Astronomer Royal Lord Martin Rees gave it a 50/50 chance. Now, he remains doubtful about humanity’s future, and discusses his fears and possible solutions with Christiane Amanpour.

Ericka Hart was diagnosed with bilateral breast cancer at the age of 28. A writer and sex-ed teacher, she realized that cancer’s impact on her identity did not feature prominently in her treatment. So she embarked on a mission to spark a broader conversation about the visibility of cancer survivors. She spoke with Alicia Menendez about pushing boundaries, and even going topless to make a point.

Paul Salopek is a Pulitzer Prize-winning journalist and National Geographic Fellow taking on the ‘Out of Eden Walk,' tracing the route our ancestors took on their global migration. He spoke to Hari Sreenivasan from the outskirts of Jaipur, India, eleven thousand miles after setting off. Follow Paul's Out of Eden Walk in real-time online: http://www.nationalgeographic.org/projects/out-of-eden-walk/

As Saudi Crown Prince Mohammed bin Salman arrives at the G20 summit in Argentina, the US Congress is souring on the Saudi/US alliance. The senate voted to end US military support for the war in Yemen, while the CIA says that MBS was directly responsible for the murder of Jamal Khashoggi. Ali Shihabi is close to the Saudi leadership, knew Khashoggi well, and spoke to Christiane Amanpour from DC.

President Trump’s former lawyer Michael Cohen pled guilty to lying to Congress about dealings with Russia, a big coup for Special Counsel Robert Mueller. Democratic Congressman Adam Schiff is the Ranking Member on the House Intelligence Committee, and in January will become its chair; he reacts to the breaking news on Cohen, as well as the latest developments regarding Saudi Arabia and Yemen.

The picture painted of the online world isn’t always pretty, with trolls and keyboard warriors. We’re advised to ignore the haters, but Dylan Marron decided to take them on. A writer, performer, and digital creator, Marron urges us, “Remember, there’s a human on the other side of the screen.” He spoke with Alicia Menendez in New York.

From Platoon to Antichrist, The Last Temptation of Christ to Spider-Man, Willem Dafoe is one of the world’s most unusual and recognisable actors. His latest role is typically intense, embodying Vincent van Gogh in a new biopic – a performance which required him to learn to paint with his director (and artist) Julian Schnabel. He spoke with Christiane Amanpour from New York.

As the war in Yemen grinds on Secretaries Mattis and Pompeo speak to U.S. senators on Capitol Hill about Saudi Arabia. With thousands of Yemenis killed and millions more on the verge of famine, Christiane Amanpour speaks with the Foreign Minister of the Houthis’ self-proclaimed National Salvation Government of Yemen, based in the capital Sana’a.

General Motors is slashing jobs and factories in important swing states Ohio and Michigan, which were crucial to President Trump’s 2016 victory. Christiane Amanpour speaks to David Urban, who was a senior advisor for Trump’s 2016 campaign and is now a member of the Trump 2020 advisory board.

Michel Martin sits down with power couple Tamia and Grant Hill. She’s a six-time Grammy-nominated singer, he’s an NBA Hall of Famer, and together they discuss politics, art and their 20-year marriage.

After a high stakes confrontation with the Russian navy, Ukraine is declaring martial law for the first time since independence in 1991. Christiane Amanpour speaks to Ukrainian President Petro Poroshenko.

Walter Isaacson sits down with Revolution CEO Steve Case, best-known for co-founding AOL, to discuss how to fix the brain drain Silicon Valley’s success has caused in the heartland.

Editor's Note: This segment incorrectly identified Walter Isaacson as a member of the Rise of the Rest Seed Fund Board of Directors.

As the British Prime Minister tries to get her Brexit deal past parliament, her Justice Minister Rory Stewart joins the program to discuss the country’s most consequential decision since the Second World War.

Alastair Campbell was spokesperson and advisor to Prime Minister Tony Blair and has fervently opposed Brexit. He weighs in on the uphill battle facing the Prime Minister to get this deal approved.

Mississippi’s Senate run-off is exposing racial and political fault lines in the Deep South. Songwriter and music producer Tena Clark discusses the impact of this race in her home state, as well as her new memoir, “Southern Discomfort.”

As a bombshell New York Times report questions Facebook’s ability to police itself, Tim O’Reilly, the man who coined the phrase “Web 2.0,” explains what’s gone wrong and how tech can fix it.

Despite acknowledging the Saudi Crown Prince may have had a role in the brutal killing of Jamal Khashoggi, President Trump says the U.S. will remain allies with Saudi Arabia. Former Secretary of Defense Leon Panetta discusses how to deal with an errant ally.

Nigerian presidential candidate Oby Ezekwesili argues she’s the right person to tackle endless corruption and violence in Africa’s most populous country.