Biochemist Jennifer Doudna tells Walter Isaacson about the extraordinary gene-editing technology, CRISPR.

The disappearance of Saudi journalist Jamal Khashoggi puts the spotlight on reporters who put their lives on the line. Celebrated correspondent Marie Colvin gave her life in Syria, and now the Hollywood actress Rosamund Pike plays her in a new film. She joins the program along with Colvin’s friend and fellow journalist Lindsey Hilsum, who has written a new biography about her life.

No sign yet of any public explanation as sources say the Kingdom is preparing to admit Jamal Khashoggi’s death was the result of a botched interrogation. CNN International Diplomatic Editor Nic Robertson joins the program from Istanbul.

Shocking reports of voter suppression ahead of the U.S. midterms. Carol Anderson, author of “One Person, No Vote,” joins the program to discuss how the rules and technicalities of voting are becoming a partisan tactic to weigh down the opposition, threatening our democracy.

Actor Paul Dano tries his hand at directing, to great reviews. Dano and his lead actress Carey Mulligan join the program to discuss the new film “Wildlife.”

As international pressure is mounting on Saudi Arabia over the shocking story of Jamal Khashoggi, former Senator Bob Graham joins the program to discuss why the U.S. has placated Saudi Arabia for nearly 20 years.

Princeton Professor Bernard Haykel, who has regular contact with the Saudi Crown Prince, Mohammad Bin Salman, weighs-in on U.S.-Saudi relations and developments on this story.

Alicia Menendez sits down with DeRay Mckesson to discuss his new memoir, “On the Other Side of Freedom: The Case for Hope,” a powerful and personal reflection on racism today.

Christiane Amanpour discusses her show, Amanpour & Company.

Hari Sreenivasan discusses the remarkable new film, “Free Solo,” with its co-director Elizabeth Chai Vasarhelyi and rock climber Alex Honnold.

British actress and Hollywood superstar Keira Knightley joins the program to discuss her latest movie on the revolutionary French writer, “Colette,” and how it strikes a chord with her own advocacy for women’s rights.

As midterms loom and the cross-party divide widens, two governors from different sides of the aisle are trying to dial down the toxic rhetoric. Ohio Governor John Kasich and Colorado John Hickenlooper discuss why their message of civility is important, now more than ever.

Michel Martin speaks to R.J. Young about his new memoir “Let it Bang: A Young Black Man’s Reluctant Odyssey Into Guns.”

The fallout over the mysterious disappearance of Saudi journalist Jamal Khashoggi continues. As all fingers point to Riyadh, author of “Presidents of War” Michael Beschloss joins the program to discuss whether President Trump will turn on a key ally.

The ranking Democrat on the U.S. Senate Foreign Relations Committee, Senator Bob Menendez, is teaming-up with his Republican colleagues to demand answers from the Saudis, and Trump. He weighs-in on whether congress will block arms sales to Saudi Arabia.

Hari Sreenivasan sits down with comedian Eric Idle, founding member of Monty Python’s Flying Circus.

As new details emerge, and fears mount that Saudi journalist Jamal Khashoggi has been murdered, critics wonder whether President Trump’s foreign policy emboldened regimes to act with impunity. New York Times correspondent David Kirkpatrick is on the ground in Ankara, Turkey, and joins the program to discuss.

The sudden resignation of UN Ambassador Nikki Haley puts the unconventional Trump foreign policy squarely in the spotlight. Veteran American diplomat James Melville says he had no choice but to quit because he could no longer defend America’s foreign policy. He joins Christiane Amanpour for an exclusive interview.

Author and British journalist Mark Urban joins the program to react to Nikki Haley’s surprise resignation as UN Ambassador, and to delve into the story of a poisoned Russian spy engulfing the U.K.

Hillary Clinton shares an urgent warning on the state of democracy and the rule of law, in an exclusive interview with Christiane Amanpour.