There are few people who have been involved in as many critical decisions as Susan Rice. Serving in numerous capacities in both the Clinton and Obama administrations, Rice has helped to significantly shape U.S. foreign policy over the past two decades. She sits down with Walter Isaacson to discuss her new memoir, "Tough Love," which reflects on her career and legacy.

It has been twelve months since the brutal murder of Washington Post journalist and vocal critic of the Saudi regime, Jamal Khashoggi, at a Saudi Embassy in Turkey. A new book by award-winning journalist Jonathan Rugman offers a fresh insight into both the methodical planning and brutal execution of Khashoggi. He joins Christiane to discuss these revelations.

With a career that has spanned over four decades and forty books, there are few novelists in the industry as successful as Patricia Cornwell. Although best known for her iconic series featuring the intrepid medical examiner Kay Scarpetta, Cornwell has now launched a whole new series sparked by the idea of a female James Bond. Christiane speaks to the author about her new book, "Quantum."

Alastair Mactaggart pushed for groundbreaking privacy change after learning how much data Google collects on its users. A novice in politics, Mactaggart learned the process that saw California adopt the toughest digital privacy law in the U.S. Now, MacTaggart tells Hari Sreenivasan how he’s adopting a fresh campaign to take on tech giants.

Turkey enters day two of its offensive on Kurds in the North East of Syria. As Trump’s decision to withdraw troops from the region continues to divide his own party, a top military official says his decision will bring about an ISIS resurgence. Nancy McEldowney, former U.S. ambassador to Bulgaria, joins the program to discuss the situation.

British Prime Minister Boris Johnson and Ireland’s leader Leo Varadkar met behind closed doors today to discuss the Irish border – a sticking point in Brexit negotiations. After the meeting, Varadkar said that he did “see a pathway to a deal,” adding that he thinks it's “possible,” to come to an agreement. John Bruton joins Christiane to discuss a possible breakthrough in the meeting.

As the host of hit TV show Shark Tank and the owner of NBA franchise, the Dallas Mavericks, Mark Cuban is one of the most recognizable entrepreneurs in the world. In recent years, he has weighed into the world of politics leaving many to speculate on whether Cuban is flirting with a Presidential run. He sits down with Walter Isaacson.

To many critics, the Trump administration’s decision to pull out of Northern Syria is impulsive and disastrous. The Turks are moving in on the territory despite U.S. threats and it exemplifies the lack of American leadership on the international stage. To get an insight into the geopolitical consequences of all of this, Christiane speaks to John Allen in an exclusive interview.

As the world continues to plunge into chaos, it offers plenty of fodder for satirists. In his time, Chris Morris has taken comedic shots at journalists, world leaders and everything in between. With his new film, "The Day Shall Come," the comedian goes after the FBI’s relentless battle against terrorism—whether it is real or fictionalized.

President Trump’s decision to withdraw a U.S. presence from Northern Syria has led long term U.S. allies, the Syrian Kurds, to suspend their fight against ISIS in the region, and instead focus their attention on a war with incoming Turkish invaders. Christiane speaks to Gülnur Aybet, a top advisor to President Erdogan.

Last year, the world was shocked by the revelations of data analysis firm Cambridge Analytica having illegally harvested and exploited the data of millions of Facebook users. The man behind the revelation was whistleblower Christopher Wylie, former director of research for the company, which didn’t survive the scandal. He speaks to Hari Sreenivasan about data crime and its dangers to democracy.

President Trump is facing a bipartisan backlash, not over Ukraine, but his decision to pull U.S. troops from northern Syria. To some, it’s seen as an abandonment of the Kurds who fought for the U.S. in the battle against ISIS. Turkish forces, who view Kurds as terrorists, want to move into the territory and push them out. Peter Galbraith joins the program fresh from traveling to Syria himself.

Today, the White House barred U.S. Ambassador to the EU Gordon Sondlanda, a key witness, from testifying to Congress over the Ukraine scandal. Chris Ruddy is a media mogul and close friend of the president, and he joins the program to dissect Trump’s thinking and approach to the impeachment investigation.

Ukraine is at the center of the ongoing impeachment investigation. Many politicians from that country have expressed horror at being sucked into this growing political firestorm, particularly while it is still fighting a war with Russia in the east. Christiane gets the Ukrainian perspective from a former deputy foreign minister.

Pioneering research is now finding that adversity or trauma experienced in childhood not only affects the mental health of adults, but could also be harmful to physical health. California Surgeon General Nadine Burke Harris has devoted her career to this research and written a book on the subject. She sits down with Michel to explain how early life experiences can shape one's body.

The climate protest group Extinction Rebellion says it has gone global today, with protests deliberately aimed to cause disruption in major cities worldwide. Jack Harries was arrested in climate protests earlier this year, and he joins the program alongside environment lawyer-turned-protester Farhana Yamin to discuss the demands of Extinction Rebellion activists.

President Trump calls it a witch hunt, but with a second whistleblower coming forward over the controversial call with the Ukrainian president, an impeachment inquiry is gathering steam. Leon Panetta has served as CIA Director, White House Chief of Staff, and Secretary of Defense, and joins the program to assess the situation and the implications for U.S. foreign policy.

Martin Kemp is Professor Emeritus of Art History at the University of Oxford, and his book "Leonardo by Leonardo" presents a stunning gallery of the master's paintings alongside Kemp's own insights, as well as the reflections of Leonardo himself. Kemp sits with Walter Isaacson, who himself wrote a highly acclaimed biography of Leonardo, to compare notes about the great man.

Chairman and CEO of the Walt Disney Company Bob Iger has been called one of the most successful CEOs in America, but his time may soon be coming to an end. Iger says he'll leave Disney in 2021, but before then, he is opening up about his journey in a new memoir "The Ride of a Lifetime." He joins Christiane to discuss Disney and his own personal struggles in his rise to the top.

San Francisco Mayor London Breed has overcome poverty and tragedy to build a political career that’s gone from strength to strength. Like many big city mayors, she’s struggling with challenges like rising homelessness and has even gone toe to toe with President Trump over the issue. She sits down with Michel in San Francisco.