Oprah Winfrey says Isabel Wilkerson's book "Caste: The Origins of Our Discontents" is a game-changer and the most important volume she's ever chosen for her book club. Wilkerson was the first Black woman to win the Pulitzer Prize for journalism. Her latest book calls out America's obsession with the term "race."

Global pandemic notwithstanding, President Trump has launched an on-again-off-again verbal war against America's leading infectious disease expert: his task force adviser, Dr. Anthony Fauci. The president recently tweeted that Fauci was "wrong" that the surge in cases is due to the country's failure to shut down properly. Fauci joins Walter Isaacson to discuss the challenges facing the U.S.

Poll after poll shows President Trump's support in steady decline, with many voters citing the pandemic response and racial equality as key election issues. Will the campaign change its strategy? Joining Christiane from Virginia to answer that question is Steve Cortes, a Trump 2020 senior adviser.

Lebanon - one of the worst hit Middle East countries from coronavirus, and teetering on the brink of economic collapse, has now been hit by a massive explosion in the capital of Beirut. Local authorities are warning that many are injured and buildings across the city have been damaged. CNN reporter Ben Wedeman was standing by on the ground for this special report.

In Mississippi, which is on track to be the top state for coronavirus infection, the school district in the city of Corinth re-opened its doors last week. Dr. Edward Lee Childress is Superintendent in Corinth. After reopening schools in his district, positive cases of COVID-19 emerged immediately. He speaks to Christiane about how his district is managing.

Megan Rapinoe is a global soccer icon: an Olympic gold medalist, Women's World Cup champion and FIFA Women's Player of 2019. She's also a role model for thoughtful political activism in sports. Now, she joins the ranks of talk show hosts, with her new HBO series "Seeing America with Megan Rapinoe," the next phase in her personal campaign for women's rights and racial justice.

Dr. Francis Collins has led public health research in the United States for 20 years. As Director of the National Institutes of Health, he is the supervisor of Dr. Anthony Fauci, the nation's top expert on infectious disease. Collins joins Walter Isaacson to offer perspective on current vaccine trials, and to discuss how his faith sustains him during this pandemic.

Arne Duncan was Secretary of Education under Barack Obama. He says the lack of leadership from Washington, and a proper national coordination plan on schools, is proving to be devastating and that the United States is failing its students.

Amid the Black Lives Matter protests, many industries have been experiencing long overdue reckonings with racism. The fashion industry is no exception. Three years ago, British Vogue elevated Edward Enninful to editor-in-chief--making Enninful the first Black gay man to hold the position. He joins Christiane to discuss his mission to strengthen diversity and inclusion at the publication.

Award-winning author James McBride has built a career exploring American culture and identity through storytelling. His latest book "Deacon King Kong" looks at how communities pull together in the face of violence and trauma. He joins Michel Martin to discuss the work.

Who is the man in the Oval Office, really? Mary Trump is President Trump's niece and a clinical psychologist. Her new memoir "Too Much and Never Enough" abandons family loyalty and the code of silence to provide a revealing portrait of her uncle. She joins Christiane to discuss.

In his latest column for the New York Times, Nobel Prize-winning economist Paul Krugman writes that the disaster unfolding in America "is what happens when you put a horrible boss in charge of running the country, and nobody can say when, if ever, the damage will be repaired."

The next COVID-related dilemma is the re-opening of schools and colleges. Eduardo Padrón is President Emeritus of Miami Dade College in Florida, a state that set records this week for single-day COVID deaths. His college enrolls more minority students than any other in the U.S. He joins Walter Isaacson to explain why he thinks higher education should be more affordable and accessible.

Barr’s intervention on behalf of two Trump allies; his role in clearing Lafayette Square of peaceful protesters; and -- most recently -- his ordering federal forces into Portland, have drawn widespread criticism and fear. To reflect on Barr’s leadership, Christiane speaks with former Democratic Senator Russ Feingold and Paul Rosenzweig, who worked in the George W. Bush administration.

Yesterday the U.S. began moving forward with President Trump's plan to withdraw some 12,000 troops from Germany. Compounding a general sense of alarm, the president this morning suggested the November election should be delayed, something scholars agree is not within presidential power. Former deputy secretary of state Tony Blinken joins Christiane to discuss.

During lockdown, people the world over have derived comfort from music. What can it teach us about peace? A new project is asking artists to express what music means to them. Behind this effort is President Obama’s sister Maya Soetoro, founder of The Peace Studio. She joins the program alongside famed cellist Yo-Yo Ma.

The pandemic has finally brought the U.S. economy to its knees. Numbers released today show the U.S. economy contracted by nearly 33% from April to June, in its worst drop on record. To discuss this catastrophic downturn and its effect on global trade, Christiane speaks with the outgoing director-general of the World Trade Organization.

The pandemic has made clear the crucial importance of public health – something Andy Slavitt knows all too well. For two years, he served under President Obama as acting administrator for the Centers for Medicare and Medicaid Services. More recently he helped Senator Bernie Sanders draft the “Masks for All” Bill. Slavitt joins Hari Sreenivasan to explain how the U.S. should tackle the pandemic.

Right now there are more than 165 coronavirus vaccines in development, with 27 already in human trials. Carl Zimmer is an award-winning science writer with a weekly column in the New York Times, and he speaks with Walter Isaacson to break down the biology of vaccines.

The murder of George Floyd sparked reflections on race, and a wave of demonstrations, around the world -- including in France, where protests challenge the culture's idea of itself as “color-blind.” This is where French comedian Fary comes in. As the star of Netflix's first French comedy special, he has sparked a renaissance in stand-up comedy at home in Paris.