ISIS leader Abu Bakr al-Baghdadi was killed in a U.S. raid. A joint U.S.-Kurdish raid reportedly also killed an ISIS spokesman, who might have succeeded the ISIS leader. Now that the leadership has been decapitated, what does it mean for ISIS and the fight against them? Rukmini Callimachi has spent years reporting on the group and Baghdadi’s leadership, and joins the program from Romania.

In the wake of the wake of Abu Bakr al-Baghdadi's death, impeachment proceedings in Washington nonetheless continue apace. Joining the program to assess this political battlefield are Republican pollster and strategist Frank Luntz and a congresswoman who sat on the House Judiciary Committee during President Nixon’s impeachment, Elizabeth Holtzman.

Basketball player Maya Moore surprised the sports world and her fans when she announced that she would be taking a sabbatical to fight for justice for her friend Jonathan Irons, who is serving a 50-year prison sentence. In 1998, a jury found him guilty of burglary and assault with a deadly weapon, but Moore is certain that Irons is innocent. She joins Michel Martin to share Jonathan's story.

Turkey, Russia and Assad’s Syrian forces have consolidated their influence in Syria while the United States' long time Kurdish allies have been left isolated. Some say that President Trump's actions are motivated by a desire to destroy the legacy of his predecessor, Barack Obama. Former Secretary of State John Kerry speaks to Christiane about policies he helped craft that are now being undone.

Theatre Legend Brian Cox sits down with Christiane Amanpour to discuss Brexit and his work in HBO's "Succession."

Harvard Law Professor Noah Feldman joins Walter to explain why the impeachment fight tests the very limits of the U.S. constitution.

Before #MeToo, there was Anita Hill. Nearly three decades ago, the law professor made the life-changing decision to testify against the confirmation of then-Supreme Court nominee Clarence Thomas, and in doing so, gripped the nation. She sits down with Christiane to discuss harassment, abuse and the politics of today.

Harvard Law Professor Noah Feldman joins Walter Isaacson to discuss the idea of a governing body for Facebook.

”Celestial Bodies” is a book of firsts: it’s the first novel by an Omani woman to be translated into English, and the first work in Arabic to be awarded the prestigious Man Booker International Prize. Author Jokha Alharthi and her co-winner and translator Marilyn Booth speak with Christiane about the book’s breakout success.

Richard Stengel is the former Editor-in-Chief of Time and a former Under Secretary of State in the Obama administration, where he led the department’s counter-disinformation efforts. He joins Walter Isaacson to discuss his new book “Information Wars,” which offers a deep dive into the fake news phenomenon, beginning with his own experience with Ukraine during the Russian invasion of Crimea.

Tom Mueller – no relation to Bob – is a New York Times bestselling author who has spent years studying the complex relationship between whistleblowers and society. His new book is a timely reminder of the challenges and the personal cost to those who dare to tell the truth, and he sits down with Michel to explain how this is ultimately about upholding American values.

U.S. Secretary of Defense Mark Esper is in Saudi Arabia today, amid the deployment of thousands of new U.S. troops to the country to try and visibly confront Iran. Meanwhile, the tumultuous withdrawal of U.S. forces from Syria looks set to benefit Iran’s regional ambitions, as well as Russia’s and the Syrian regime’s. Esper joins Christiane for an exclusive interview in Saudi Arabia.

Rhiannon Giddens is a folk singer and multi-instrumentalist who also happens to be a classically trained opera singer. Having grown up in North Carolina, she’s now on a mission to re-frame the history of African Americans and their contributions to the musical landscape. Giddens sits down with Walter to discuss her latest album, “There Is No Other,” and play a little banjo.

Christiane sits down with Peter Frankopan and Malte Herwig to discuss Peter Handke's controversial Nobel Prize Win. WARNING: This segment contains graphic images.

Grayson Perry is a London-based contemporary sculptor, carpet weaver, print-maker and ceramicist. His work challenges the fashions and foibles of the world’s collector class, while his public experiments in gender identity challenge our own innate prejudices. His latest exhibition is typically sly, with the barbed title of “Super Rich Interior Decoration.” Christiane joins him in the gallery.

Gulalai Ismail has been an advocate for human rights in Pakistan since she was 16 years old. For years, she has spoken out about abuses against women and girls, and last year, she began to advocate for victims of alleged sexual assault by Pakistan’s army – and for that, she has paid a very big price. She sits down with Michel Martin to discuss her experiences.

In testimony to the Congressional impeachment inquiry, the U.S. Ambassador to the EU Gordon Sondland says that President Trump directed him to work through Rudy Giuliani rather than government channels. It’s the latest development in the impeachment saga, much of which has focused on conflicting claims of corruption. Ukraine and disinformation expert Nina Jankowicz joins the program to discuss.

The UK and the EU have announced a Brexit deal – again. Prime Minister Boris Johnson’s attempt to renegotiate Theresa May’s deal defied the odds and found success, but it still needs approval from the European and UK Parliaments, with the latter being a particularly difficult hurdle to clear. Jonathan Powell joins the program to weigh in on the situation.

After a contentious meeting at the White House, House Leader Nancy Pelosi says she warned President Trump that, “the Russians have been trying to get a foothold in the Middle East for a very long time, unsuccessfully, and now the president has given them the opportunity" by pulling troops out of Northern Syria. Mikhail Kasyanov joins the program to explain Putin's role in this situation.

Deepak Chopra is a bestselling author, New Age wellness guru and integrative medicine advocate. He became famous for teaching household names such as Oprah and Madonna how to meditate. His books have been translated into dozens of languages and his 89th book is "Metahuman: Unleashing Your Infinite Potential." He sits down with Hari to discuss the state of the world.