The Omicron coronavirus variant has the world on edge. At least 70 countries and territories have imposed travel restrictions on African countries since South Africa alerted the world to the variant. Epidemiologist and infectious disease specialist Dr. Céline Gounder was a member of the Biden-Harris transition COVID-19 advisory board, and she joins Walter Isaacson to discuss the latest.

A new documentary is being hailed as “the most inspiring journalism movie – maybe ever” by The Washington Post. "Writing With Fire" follows a group of journalists from India’s most marginalized caste, the Dalits, and their fight to keep India’s only female-led news outlet operating. The filmmakers discuss the project and what it reveals about India's relentless gender and caste discrimination.

House Democrat Jackie Speier has announced she won’t seek reelection after nearly 14 years in Congress. Back in 1978, she narrowly survived the infamous Jonestown Massacre, and she explains to Michel Martin how it was that this moment inspired her life in public service—and why she has chosen to step back.

Nathan Myhrvold spent 14 years climbing the ranks at Microsoft to become the company's first CTO—and then he left the tech world behind to pursue his dream of attending culinary school. He went on to found Modernist Cuisine, a research lab and publishing house exploring the cutting edge of cooking. Myhrvold discusses his latest series of books, which explore the history and science behind pizza.

Tom Morello is best known as the guitarist of the rock band Rage Against the Machine, but you'll find his latest work in print. He's writing a series of essays on his music and social justice for The New York Times, all while preparing to release his new album next month -- as he discusses with Hari Sreenivasan.

If you think you know all there is to know about the Fab Four, think again. None other than Oscar-winning director Peter Jackson has worked his Lord of the Rings magic on an archive of footage over 50 years old, providing a whole new view of some of The Beatles' last recording sessions.

Is the U.S. job market emerging satisfactorily from the impact of the pandemic? Walter Isaacson speaks with Labor Secretary Marty Walsh.

One of the most influential anime series of all time has been given the live-action Netflix treatment. "Cowboy Bebop" is an action-packed Western set in space, decades in the future. At a time when diversity is the hot topic in Hollywood, John Cho sits down with Hari Sreenivasan to discuss his journey as an actor and what it means to be part of such a well-loved project.

In focus tonight: Dr. Natalie Dougé, one of the subjects of the harrowing documentary "The First Wave," by director Matthew Heineman. The film takes viewers inside one of New York's hardest-hit hospitals. Dougé and Heineman join Hari Sreenivasan to share their memories from the early stages of the pandemic.

Rachel Vindman was thrust into the national spotlight after her husband, Alexander, blew the whistle on President Donald Trump's alleged abuses of power. In her new podcast, Vindman talks about her breakup with the Republican Party -- and a larger trend of suburban women following suit.

Billy Porter made his name as Lola in "Kinky Boots" before going on to become the first openly gay Black man to win an Emmy as lead actor for "Pose," and a key figure in the movement to de-gender fashion. Porter’s new autobiography, "Unprotected," is a powerful reflection on race, sexuality, art, and healing. He speaks about fame and grappling with the structures surrounding masculinity.

Carlos Santana is a musician who needs little introduction. His music blends a unique mix of rock, jazz and influences from his Mexican heritage. His band recently released their new album called “Blessings and Miracles.” He joins Walter Isaacson to explain what inspired this latest album and the people and experiences that shaped the artist he is today.

John McWhorter is a bestselling author and linguist, and he's out with a new book called "Woke Racism." Here he is with Walter Isaacson discussing his theory and solutions for a more just and equitable America.

The Washington Post has conducted an extensive investigation into January 6 called "The Attack: Before, During and After." It included more than 75 journalists and interviews with over 230 people, showing a firm commitment to establishing the facts. Michel Martin speaks with Post reporters Amy Gardner and Aaron Davis about the cascade of warnings received before January 6th.

The new Hulu drama "Dopesick" tells the story of Purdue Pharma's highly addictive painkiller Oxycontin and its tragic ripple effect on communities throughout the country. Actors Peter Sarsgaard and John Hoogenakker join Hari Sreenivasan to discuss their roles in the project and the urgency of the opioid crisis.

Best known as a correspondent for "The Daily Show with Trevor Noah," stand-up comic Roy Wood Jr. is noted for satire that confronts the tough topics head-on. His new hour-long special for Comedy Central, "Imperfect Messenger," takes on everything from race and police reform to mass shootings and celebrity activism. Here is Roy Wood Jr. talking to Hari Sreenivasan.

We take a look at how one man shook the foundations of American democracy by tearing up the Constitution in a time of deadly peril. Harvard Law professor and Bloomberg columnist Noah Feldman's new book "The Broken Constitution" examines President Lincoln’s thought processes as he rewrote the rulebook and grappled with challenges from both political rivals and passionate abolitionists.

Tsedale Lemma is an Ethiopian journalist and the founder of the Addis Standard magazine. She has testified before the House Foreign Affairs Committee and has written for The New York Times. She joins the program to discuss what could come next for her country.

The father and daughter duo Chase and Tokata Iron Eyes were key figures in the 2016 protest against the Dakota Access Pipeline. They speak with Hari Sreenivasan about how their tribe’s demonstrations moved the dial and why their fight for indigenous justice continues.

What is it like to walk alongside history? As Hillary Clinton's top aide, Huma Abedin knows all too well. She usually prefers to stay out of the spotlight, but Abedin’s private life became a public scandal around the actions of her then-husband, Anthony Weiner – a scandal that some say ultimately cost Clinton the presidency in 2016.