Walter Isaacson sits down with Ben Jaffe, to discuss a new documentary “A Tuba to Cuba,” exploring the legacy of his family, known as saviours of New Orleans jazz, and why he believes diversity is at the core of the genre.

As the President keeps up his verbal assault on the Mueller investigation, award-winning author and national security expert Tim Weiner joins the program to discuss who will protect the rule of law.

As government ministers resign in Britain over their Prime Minister’s Brexit plan, former Head of the Foreign Office Simon Fraser joins the program to weigh-in on the country’s state of turmoil.

Paul Simon is a musical shapeshifter whose career spans decades. He’s now releasing a new album “In the Blue Light” and sat down with Christiane Amanpour on the heels of a global farewell tour, to discuss his life, work and new music.

Hari Sreenivasan sits down with entrepreneur Casey Gerald to discuss his new memoir “There Will Be No Miracles Here” and his amazing life story.

Roger Ailes reshaped American media and politics by founding Fox News. Christiane Amanpour talks to Alexis Bloom, the director of the new documentary “Divide and Conquer: The Story of Roger Ailes,” as well as Alisyn Camerota, an anchor who worked closely with Ailes at Fox News.

As Iran calls newly re-imposed U.S. sanctions “an act of economic war,” the Iranian Ambassador to the UK, Hamid Baeidinejad, joins the program.

Abbi Jacobson, one of Comedy Central’s biggest stars, joins the program to discuss her hit comedy “Broad City” as well as a new memoir reflecting on love, loss and work.

As we come to grips with the dangers of digital media, Walter Isaacson speaks with Jennifer Pahlka, a tech innovator and founder of Code for America, who argues technology is still a force for good.

As California residents face an unprecedented disaster, in an exclusive interview, Christiane Amanpour speaks to Gov. Jerry Brown about the worst fires in California history.

On her first day in the job, the new head of Planned Parenthood Dr. Leana Wen joins the program to discuss what the organization means to her and its role in a country where healthcare is at the center of political debate.

Timothy Snyder, leading historian and bestselling author, joins the program to discuss the battle of ideas that took place over the weekend in Paris as French President Emanuel Macron hosted world leaders, including President Trump, to mark 100 years since the end of WWI.

In the US, 20 states have filed a lawsuit to repeal pre-existing condition protection from the Affordable Care Act. New York Times bestselling author and journalist Kurt Eichenwald joins the program to discuss what it’s like to navigate the country’s healthcare system with epilepsy, and the struggles he has faced with discrimination, medical incompetence, and sexual abuse.

In the wake of high-profile mass shootings in the US, some doctors are calling for a public health approach to tackle gun violence. Dr. Judy Melinek joins the program to discuss the role of doctors in the gun debate, tensions between some doctors and the NRA, and the #ThisISMyLane and #ThisISOurLane movements.

Wall Street giant Jamie Dimon joins the program from Paris – where he is launching a $30 million investment into Seine-Saint-Denis, one of France’s poorest districts – to discuss the economy, populism, and his spat with President Trump.

In Tuesday’s election, Democratic candidate Tom Malinowski beat his Republican rival in a seat the GOP had held since 1981. A former Assistant Secretary of State for Human Rights under President Obama, Malinowski joins the program to discuss the midterms and President Trump’s foreign policy.

Kurt Andersen is a Peabody Award-winning host of the podcast Studio 360, a best-selling novelist, and acclaimed cultural critic. He joins Walter in studio to examine the growing divide in our nation and how we can reclaim our collective understanding and appreciation for facts and truth in an era of blurred lines.

CNN’s Poppy Harlow sat down recently with Canadian Prime Minister Justin Trudeau to discuss gender parity, trade deals, and Saudi Arabia, and we bring you highlights from that exclusive conversation.

President Obama described Brittany Packnett as a voice to “make a difference for years to come,” and she has campaigned for police reform, was part of the Black Lives Matter movement, and established Teach For America’s first civil rights agenda. Alicia Menendez spoke with her in New York.

The firing of Attorney General Jeff Sessions raises serious constitutional questions, and could risk undermining the Mueller investigation. With Democrats in the House readying to launch investigations, Christiane speaks with Harvard Law Professor Laurence Tribe about what could amount to a constitutional crisis.