As the new administration tackles an array of challenges, senior cabinet secretaries are getting to work. Today is the first full day in office for new treasury secretary Janet Yellen, the first woman in that position. What challenges lie ahead for her? Jack Lew, who held her position from 2013 to 2017, joins Hari Sreenivasan to discuss.

A new report from the International Monetary Fund projects global economic growth at 5.5% for the year. But this is far from certain, particularly if vaccines fail to keep up with new COVID variants. Moreover, the recovery is expected primarily to benefit the wealthy, marginalizing the poor and ignoring the issue of income inequality. Christiane discusses all of this with the IMG Managing Director

As the economic fallout from the pandemic perpetuates Americans’ suffering, many are arguing that President Biden should follow up on his promise to quickly put money into the pockets of the American people. One of those making the case is author and New York Times columnist Ezra Klein, who launches his new podcast this week. He explains to Walter Isaacson his thoughts on bipartisanship.

The first big tennis event of 2021 is the Australian Open, beginning February 8. But some of the world’s top players will be warming up in their hotel rooms, under strict quarantine. World No. 2-ranked player Rafael Nadal is in that unenviable position as he prepares for competition. But, as Nadal explains to Christiane from his hotel room, he’s happy in quarantine, just as he is in life.

Today, global leaders convened remotely for the Climate Adaptation Summit to share ideas on a response to the climate crisis, with the U.S. represented by President Biden’s new climate envoy John Kerry. But what is a possible route out of the crisis? Professor Michael Mann has a few ideas in his new book, which lays out a battle plan for saving our environment.

The Biden administration is already facing a major diplomatic test, as this weekend saw demonstrators in Russia coming out in huge numbers to protest the detention of opposition leader Alexey Navalny. What significance do these protests hold, and how should the Biden administration respond? International relations experts Evelyn Farkas and Nina Khrushcheva join Christiane to discuss.

25 million coronavirus cases have now been reported in the U.S., with vaccines a rare light at the end of the tunnel – despite ongoing problems in their rollout. Two ER doctors on the front line join Hari Sreenivasan to explain how more lives can be saved through earlier diagnosis.

President Biden has unveiled a new national strategy to replace the ad-hoc patchwork of policies from 50 states under the previous administration. The plan is to pick up the pace of distribution to meet the goal of 100 million vaccinations in Biden's first 100 days in office. Andy Slavitt is a senior advisor to the new response team. He joins Hari Sreenivasan to explain the team's upcoming goals.

A new documentary, "The Human Factor," looks at Israel-Palestinian peace efforts through the eyes of key American negotiators. The film examines the personal stories hidden within this complicated, historic conflict. Director Dror Moreh joins Christiane alongside two key players featured in the film: a veteran Middle East negotiator Aaron David Miller and former senior policy adviser Gamal Helal.

This week, the EU invited President Biden to a summit focused on shared multilateral goals, COVID, and climate. Prime Minister Micheál Martin, referring to Biden's Irish ancestry, has said, "He is one of us, part of our global family." Martin joins Christiane from Dublin to react to Biden's inauguration and discuss the state of the pandemic in Ireland.

Vice President Kamala Harris cracked the penultimate glass ceiling today, marking a historic moment in American politics. There is perhaps no more famous campaigner for women’s rights than Gloria Steinem, who speaks with Michel Martin alongside Farai Chideya, host of the podcast "OurBodyPolitic."

The pandemic is President Biden’s immediate concern. But his presidency also marks a crucial pivot for America’s overseas alliances. Joining Christiane to assess the future of U.S. foreign policy are former UK diplomat Sir Peter Westmacott and former State Department, Defense Department, and National Security Council official Kori Schake.

President Biden comes to power pledging to put his whole soul into uniting America. History was also made, as Vice President Kamala Harris became the first African American, first South Asian, and first woman to ever hold that position. To discuss what this day means and where America goes from here, Christiane speaks with two eminent writers and thinkers on the American experiment.

President Biden is unveiling a national strategy to tackle COVID-19, inviting Congressional leaders to the White House as early as Friday to discuss his plan. Devi Sridhar is the chair of Global Public Health at the University of Edinburgh. She spoke to Christiane about how Biden can best implement a federal pandemic plan.

Four years of President Trump had led to tense relationships with key allies, including members of NATO -- one of the most important American-led security organizations. Christiane spoke with NATO Secretary-General Jens Stoltenberg about his hopes of rebuilding the transatlantic partnership under a Biden administration.

The United States' allies around the world are wary of the hostile and fractured political climate in the U.S. The Democrats, now in control of the White House and both chambers of Congress, have a long list of urgent priorities. What will happen to them when the Trump impeachment moves to the Senate for trial? Senior Democratic Congressman Adam Schiff joins Christiane to discuss.

On the night before his inauguration, President Biden led a memorial for the 400,000 Americans who have died from coronavirus. "To heal, we must remember," he said. As we know, Biden's own life has been shaped by tragedy and personal loss. David Kessler, an expert on death and grieving, is the author of "Finding Meaning: The Sixth Stage of Grief." He spoke with Michel Martin.

Cedric Richmond is an incoming senior presidential adviser and director of the White House Office of Public Engagement. Richmond has spent the last decade representing Louisiana in Congress and led the Congressional Black Caucus from 2017 to 2019. He speaks with Walter Isaacson about why he believes it’s crucial the new administration works with colleagues across the aisle.

As he finishes his presidency, President Trump has broken yet another norm: pausing executions during a presidential transition. A frenzy of executions has swept through federal death row, more than any presidency in 100 years. To discuss all this, Christiane speaks with human rights lawyer and civil rights activist Bryan Stevenson.

Since the election, Fox News has been losing viewers to more right wing stations like Newsmax and OANN. Shepard Smith strove to be a credible source of hard news at the network for more than 20 years. In 2019, he left and now anchors his own show on CNBC. He joins the show to discuss what role he thinks Fox News has played in muddying the information ecosystem.